Irresistible Spicy Southern Chicken Spaghetti Casserole

Name: Irresistible Spicy Southern Chicken Spaghetti Casserole
Prep time: 20 min
Cook time: 4 h
Total time: 4 h 20 min
Yield: 6 servings
Ingredients: 2 cups cooked spaghetti; 1 pound chicken breast, cooked and shredded; 1 can (10.5 oz) cream of chicken soup; 1 cup salsa; 1 cup shredded cheddar cheese; 1 teaspoon cayenne pepper; 1 teaspoon garlic powder; Salt and pepper to taste; 1/2 cup green onions, chopped

Highlighted under: Comfort Food

Savor the comforting fusion of flavors in this Irresistible Spicy Southern Chicken Spaghetti Casserole. This hearty dish combines tender chicken, zesty seasonings, and a creamy sauce, all baked with pasta to create a mouthwatering casserole perfect for family dinners or potlucks. Easy to prepare in your crockpot, it's a deliciously satisfying meal that brings a spicy twist to classic comfort food.

Created by

Georgia Lane

Last updated on 2025-11-27T06:24:33.402Z

This dish is a delightful blend of Southern flavors, combining the warmth of spices and the richness of creamy sauces. It's perfect for bringing the family together during mealtime.

A Flavorful Comfort Food Classic

Chicken spaghetti casserole is a beloved dish that combines the warmth of home-cooked comfort food with a delightful medley of flavors. The classic elements of tender chicken, creamy sauce, and hearty pasta make this dish a go-to for family gatherings and weeknight dinners alike. With its rich and inviting taste, it’s no wonder why this casserole is often a favorite among all ages.

This recipe takes the traditional chicken spaghetti and adds a spicy Southern twist, elevating it to new culinary heights. The blend of zesty salsa and spicy cayenne pepper infuses the dish with an exciting kick that sets it apart. Your family and friends will be asking for seconds, making it perfect for those who enjoy a hint of heat in their meals.

Perfect for Any Occasion

Whether it’s a cozy family dinner or a potluck with friends, this casserole is the ideal option for those looking to impress. Its ease of preparation, especially when made in a crockpot, means you can spend less time in the kitchen and more time enjoying the company of loved ones. Simply set it up, let it cook, and serve when you’re ready!

This dish also accommodates various dietary preferences and can be customized based on what you have on hand. You can easily swap out chicken for turkey or add in some veggies for extra nutrition. No matter how you choose to make it, the Irresistible Spicy Southern Chicken Spaghetti Casserole remains a delightful centerpiece that brings people together.

Tips for the Best Casserole

To make this casserole truly shine, consider using freshly cooked chicken seasoned to your liking. Brining the chicken beforehand can add additional flavor and moisture, ensuring that it stays juicy and tender. Also, don’t hesitate to experiment with your favorite types of cheese; pepper jack or Monterey Jack can add an exciting twist to the topping mix.

Lastly, let the flavors meld by allowing the casserole to cool slightly before serving. This allows the creamy sauce to thicken a bit, making for a better-holding dish that is easier to serve. Trust us, it will be worth the wait!

Ingredients

Main Ingredients

2 cups cooked spaghetti
1 pound chicken breast, cooked and shredded
1 can (10.5 oz) cream of chicken soup
1 cup salsa
1 cup shredded cheddar cheese
1 teaspoon cayenne pepper
1 teaspoon garlic powder
Salt and pepper to taste
1/2 cup green onions, chopped

Make sure to have all your ingredients prepped before you start!

Instructions

Prepare the Chicken

In a large bowl, combine the cooked and shredded chicken with the cream of chicken soup, salsa, and spices. Mix well.

Combine with Spaghetti

Add the cooked spaghetti to the chicken mixture and stir until everything is evenly coated.

Bake the Casserole

Transfer the mixture to a crockpot. Top with shredded cheddar cheese and green onions.

Cook on low for 4 hours.

Serve and Enjoy

Once cooked, serve hot and enjoy your delicious casserole!

Pair this casserole with a fresh salad or some garlic bread for a complete meal.

Serving Suggestions

This amazing casserole can stand alone, but pairing it with a fresh green salad or some warm garlic bread can elevate your meal even further. The crunch and freshness of a salad provide a lovely contrast to the creamy and rich casserole, while garlic bread is perfect for scooping up every last bite.

For an extra kick, consider serving it with a side of jalapeño cornbread or tortilla chips. These accompaniments not only enhance the Southern theme but also add texture and flavor that complements the spicy casserole beautifully.

Storing and Reheating

If you find yourself with leftovers, storing this casserole is easy. Simply place it in an airtight container in the refrigerator, where it can last for up to three days. When you’re ready to enjoy it again, you can reheat individual portions in the microwave for a quick meal or pop the entire casserole back in the oven at 350°F until heated through.

For longer storage, consider freezing leftovers. To do this, let the casserole cool completely, then wrap it tightly with aluminum foil or plastic wrap and store in the freezer for up to three months. Thaw it overnight in the fridge before reheating, and enjoy the deliciousness all over again!

Why This Recipe Stands Out

What sets this Irresistible Spicy Southern Chicken Spaghetti Casserole apart from others is its perfect harmony of flavors. The combination of savory chicken, spicy salsa, and creamy soup creates a mouthwatering experience that is both comforting and exciting. This dish truly caters to diverse taste buds, ensuring everyone at the table enjoys it.

Moreover, the use of readily available ingredients makes this recipe a breeze for home cooks at any skill level. With its simple preparation and bold flavors, it’s no wonder this casserole is becoming a staple in many households, proving that comfort food can be both simple and scrumptious!

Questions About Recipes

→ Can I use different pasta?

Yes, any pasta can be used, but spaghetti works best for this recipe.

→ Can I make this casserole ahead of time?

Absolutely! You can prepare it a day in advance and cook it when you're ready.